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KMID : 0387720070180030254
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Korean Journal of Blood Transfusion
2007 Volume.18 No. 3 p.254 ~ p.259
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Plasma Exchange in a Patient with Antineutrophil Cytoplasmic Antibody-associated Vasculitis.
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Lee Yun-Soo
Park Jung-Ran
Song Kyu-Sub
Kim Yong-Lim
Suh Jang-Soo
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Abstract
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Antineutrophil cytoplasmic antibody (ANCA)-associated vasculitis is a systemic autoimmune disease with a poor prognosis in untreated patients, and combination therapy with steroidsand cyclophosphamide is the current standard treatment. Treatment with immunosuppressive agents results in high remission rates; however, there is a considerable morbidity related to the immunosuppressive state, such as life-threatening infections. To reduce serious immunosuppressant-related adverse effects, potentially promising treatment options, including plasma exchange, cytapheresis, administration of intravenous immunoglobulin and TNF-alpha blocking agents have been developed. We performed plasma exchange with steroid pulse therapy for a 52 year-old female patient with pulmonary hemorrhagewith ANCA-associated crescentic glomerulonephritis. After combination therapy, the pulmonary hemorrhage and renal function recovered and myeloperoxidase (MPO)-ANCA decreased.
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KEYWORD
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ANCA, Vasculitis, Plasma exchange
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